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Abstract Objectives: Glutathione S-transferase alpha (GST) is an important antioxidant enzyme closely associated with the onset and progression of neurodegenerative diseases

Some high risk groups for vitamin B12 deficiency include: elderly people- often stomach acid production decreases with age individuals who have had intestinal surgery such as weight loss surgery or laparoscopies individuals with GI issues including celiac disease, IBD, IBS (MOST OF YOU!!!) those following a vegetarian or vegan diet- due to the lack of animal protein eaten (one of the main sources of B12) individuals with pernicious anemia- do not make intrinsic factor Notice how a fair amount of the high risk individuals are those with some sort of intestinal issue

Liver enzyme elevation is a concern many encounter, especially when starting a new medication

An unusual cause of severe metabolic acidosis

There are no major supplements that are known to negatively interact with glutathione

NICE guidance and British Society for Sexual Medicine (BSSM) guidelines provide clear criteria for initiation and monitoring of testosterone therapy